Genetically engineered yeast
US9868966B2 · kind B2 · utility
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Key dates
| Filing date | Oct 10, 2013 |
| Grant date | Jan 16, 2018 |
| Priority date | — |
| Expiry date | Apr 13, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y604/01001
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A genetically modified Saccharomyces cerevisiae including an active fermentation pathway producing 3-HP expresses an exogenous gene expressing the aminotransferase YhxA from Bacillus cereus AH1272 catalyzing a transamination reaction between beta-alanine and pyruvate to produce malonate semialdehyde. The yeast may also express a 3-hydroxyisobutyrate dehydrogenase (HIBADH) and a 3-hydroxypropanoate dehydrogenase (3-HPDH) and aspartate 1-decarboxylase. Additionally the yeast may express pyruvate carboxylase and aspartate aminotransferase.
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