Cross-linked sodium hyaluronate gel for tissue filler for plastic surgery and preparation method thereof
US9872827B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 26, 2013 |
| Grant date | Jan 23, 2018 |
| Priority date | — |
| Expiry date | Sep 24, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08J2305/08
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a cross-linked sodium hyaluronate gel for tissue filler for plastic surgery and the preparation method thereof. The alkaline solution of sodium hyaluronate reacts with the long chain alkane containing epoxy group and the cross-linking agent containing epoxy group for 2˜5 hours at 35° C.˜50° C. to produce cross-linked sodium hyaluronate, then washed, gelled and sterilized, to prepare the gel. Among which, the molar ratio of sodium hyaluronate:cross-linking agent containing epoxy group:long chain alkane containing epoxy group is 10:4˜1:1˜4; the number of carbon atoms of the said long chain alkane containing epoxy group is 6 to 18. The gel prepared in the present invention can, on one hand, effectively enhance the resistance to enzymolysis to become more stable, and on the other hand, maintain the excellent biocompatibility of sodium hyaluronate without affecting its injectability.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.