Bone and metal targeted polymeric nanoparticles
US9872881B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Nov 3, 2014 |
| Grant date | Jan 23, 2018 |
| Priority date | — |
| Expiry date | Nov 3, 2034 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/6957
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Bone- and metal-targeted polymeric nanoparticles are provided. Exemplary nanoparticles have three main components: 1) a targeting element that can selectively bind to bone, minerals, or metal ions; 2) a layer of stealth to allow the polymer to evade immune response; and 3) a biodegradable polymeric material, forming an inner core which can carry therapeutics or other diagnostics. Preferred nanoparticles contain a blend of target-element polymer conjugate and polymer that optimizes the ligand density on the surface of the nanoparticle to provide improved targeting of the nanoparticle. The ratio of target-element polymer conjugate to polymer can also be optimized to improve the half-life of the nanoparticles in the blood of the subject. The nanoparticles also exhibit prolonged, sustained release of therapeutic agents loaded into the particles.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.