TFPI inhibitors and methods of use

US9873720B2 · kind B2 · utility

Assignee

• Baxalta Incorporated · CH

Inventors

• Michael Dockal · Wien, AT
• Rudolf Hartmann · Bisamberg, AT
• Friedrich Scheiflinger · Wien, AT
• Frank Osterkamp · Berlin, DE
• Thomas Polakowski · Berlin, DE
• Ulrich Reineke · Berlin, DE

Key dates

• Filing date: Dec 29, 2014
• Grant date: Jan 23, 2018
• Expiry date: Dec 13, 2035

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2500/20
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides peptides that bind Tissue Factor Pathway Inhibitor (TFPI), including TFPI-inhibitory peptides, and compositions thereof. Peptide complexes also are provided. The peptides may be used to inhibit a TFPI, enhance thrombin formation in a clotting factor-deficient subject, increase blood clot formation in a subject, treat a blood coagulation disorder in a subject, purify TFPI, and identify a TFPI-binding compound.