Polypeptides

US9873729B2 · kind B2 · utility

Assignee

• AFFIBODY AB · SE

Inventors

• Caroline Ekblad · Boo, SE
• Elin Gunneriusson · Hallsberg, SE
• Malin Lindborg · Boo, SE
• Lars Abrahmsen · Bromma, SE
• John Löblom · Huddinge, SE
• Torbjörn Gräslund · Åtvidaberg, SE
• Johan Seijsing · Stockholm, SE

Key dates

• Filing date: Mar 17, 2014
• Grant date: Jan 23, 2018
• Expiry date: Mar 17, 2034

Classification

• Technology area (CPC —): General

Abstract

The present disclosure relates to a class of engineered polypeptides having a binding affinity for the neonatal Fc receptor (in the following referred to as FcRn), and provides an FcRn binding polypeptide comprising the sequence EX2X3X4AX6X7 EIRWLPNL X16X17X18QRX21 AFIX25X26LX28X29 (SEQ ID NO: 1075). The present disclosure also relates to the use of such an FcRn binding polypeptide as an agent for modifying pharmacokinetic and pharmacodynamic properties and as a therapeutic agent.