NAD biosynthesis and precursors for the treatment and prevention of cancer and proliferation

US9877981B2 · kind B2 · utility

Assignees

• President and Fellows of Harvard College · US
• NewSouth Innovations Pty Limited · AU

Inventors

• David A. Sinclair · Feldkirchen-Westerham, DE
• Ana P. Gomes · New York, US
• Lindsay Edward Wu · Sydney, AU

Key dates

• Filing date: Oct 9, 2013
• Grant date: Jan 30, 2018
• Expiry date: Nov 25, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Y207/07001
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are novel compositions and methods for the treatment of age-related diseases, mitochondrial diseases, the improvement of stress resistance, the improvement of resistance to hypoxia and the extension of life span. Also described herein are methods for the identification of agents useful in the foregoing methods.Methods and compositions are provided for the treatment of diseases or disorders associated with mitochondrial dysfunction.The invention relates to methods for treatment and prevention of cancer by administering agents that increase levels of NAD+, such as NAD+ precursors or agents involved in NAD+ biosynthesis.