Immunoassay of S-adenosylmethionine using analogs thereof and personalized therapeutics
US9877982B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 18, 2014 |
| Grant date | Jan 30, 2018 |
| Priority date | — |
| Expiry date | May 18, 2034 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/7033
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of detecting the presence or absence of a disease in a patient wherein said disease is accompanied by deficient levels of S-adenosylmethionine comprising: identifying a patient that is suspected of having said disease or is at risk of having said disease; obtaining a biological sample from said patient; determining the level of S-adenosylmethionine in said biological sample using an antibody derived from a hapten analog of S-adenosylmethionine; and correlating the level of S-adenosylmethionine in said biological sample with the presence or absence of said disease. The invention also provides methods for measuring SAH which is used to determine the methylation index (ratio of SAM/SAH) in biological fluids which is indicative of the health status of an individual.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.