Methods and compositions for regulating SRCA2A expression levels in myocardial infarction
US9877997B2 · kind B2 · utility
1Cited by
5References
10Claims
0Family size
Assignee
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Key dates
| Filing date | Jun 24, 2014 |
| Grant date | Jan 30, 2018 |
| Priority date | — |
| Expiry date | Jun 24, 2034 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P9/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The disclosure provides methods and compositions for increasing SERCA2a expression levels in a mammalian subject in need thereof. The methods comprise administering to the subject a therapeutic amount of an aromatic-cationic peptide to subjects in need thereof. In some embodiments, the aromatic-cationic peptide is D-Arg-2′6′-Dmt-Lys-Phe-NH2, or a pharmaceutically acceptable salt thereof such as acetate or trifluoroacetate salt. In some embodiments, the subject has suffered a myocardial infarction.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.