Compounds for selective histone deacetylase inhibitors, and pharmaceutical composition comprising the same
US9878986B2 · kind B2 · utility
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7Claims
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Key dates
| Filing date | Apr 29, 2014 |
| Grant date | Jan 30, 2018 |
| Priority date | — |
| Expiry date | Apr 29, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D417/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Provided are urea derivatives of Formula I:with histone deacetylase (HDAC) inhibitory activity, optical isomers thereof, pharmaceutically acceptable salts thereof and pharmaceutical compositions comprising the same. The provided urea derivatives of Formula I are selective histone deacetylase (HDAC) inhibitors and are effective for the treatment of histone deacetylase-mediated diseases such as malignant tumors, inflammatory diseases, rheumatoid arthritis, and neurodegeneration.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.