2-H-indazole derivatives as cyclin-dependent kinase (CDK) inhibitors and therapeutic uses thereof

US9878994B2 · kind B2 · utility

Assignee

• BETA PHARMA, INC. · US

Inventors

• Michael N. Greco · Lansdale, US
• Michael John Costanzo · Bonney Lake, US
• Jirong Peng · Mequon, US
• Victoria Lynn Wilde · Montclair, US
• Don Zhang · Princeton, US

Key dates

• Filing date: Jul 24, 2015
• Grant date: Jan 30, 2018
• Expiry date: Jul 24, 2035

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Indazole compounds of formula (I) as cyclin-dependent kinase (CDK) and cell-proliferation inhibitors, and therapeutic uses and methods of preparation thereof, are disclosed. These compounds, and pharmaceutically acceptable salts, solvates, prodrugs, and pharmaceutical compositions thereof, are useful for treating diseases and disorders associated with activity of cyclin-dependent kinases, in particular CDK4/6, including but not limited to various cancers and inflammation-related diseases or conditions.