Patent · US Active

Restoring phosphorylation of a novel PINK1 substrate to treat parkinson's disease

US9879233B2 · kind B2 · utility

0Cited by

0References

9Claims

0Family size

Assignees

VIB VZW · BE
Katholieke Universiteit Leuven · BE

Inventors

Bart De Strooper · Leuven, BE
Patrik Verstreken · Blanden, BE
Vanessa Morais Epifânio · Kessel-Lo, BE

Key dates

Filing date	Nov 7, 2013
Grant date	Jan 30, 2018
Priority date	—
Expiry date	Dec 18, 2033

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Y106/99003
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present application relates to the field of Parkinson's disease (PD), particularly sporadic PD or PD associated with mutations in the mitochondrial kinase PINK1. A new substrate for this kinase, NdufA10, is identified herein. In Parkinson's disease, this protein is dephosphorylated, which is linked to a loss of mitochondrial membrane potential. It is shown that restoring or mimicking phosphorylation of NdufA10 restores the phenotypic defects associated with Parkinson's disease and is thus a new therapeutic paradigm.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.