Modulation of RNA activity and vascular permeability
US9879255B2 · kind B2 · utility
0Cited by
4References
16Claims
0Family size
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Key dates
| Filing date | Oct 2, 2013 |
| Grant date | Jan 30, 2018 |
| Priority date | — |
| Expiry date | Oct 2, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/3231
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides oligonucleotides that inhibit the binding of miR-27a to VE-cadherin mRNA, particularly in the form of blockmirs. The invention also provides compositions comprising such oligonucleotides and methods of use of such oligonucleotides to modulate the activity of VE-cadherin, inhibit or reduce vascular permeability, treat or prevent a vascular permeability-associated disease or condition, inhibit tumor growth, treat ischaemic injury, enhance recovery from ischaemic injury, treat surgical wounds and/or promotes post-operative recovery, and promote or induce angiogenesis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.