Rational design of components of the oligo-saccharyltransferase-catalysed asparagine-linked glycosylation
US9881124B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 3, 2012 |
| Grant date | Jan 30, 2018 |
| Priority date | — |
| Expiry date | May 6, 2032 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/924
- WIPO fieldComputer technology
- WIPO sectorElectrical engineering
Abstract
The present invention is directed to methods for identifying or designing (a) a potential oligosaccharide donor, (b) a potential oligosaccharyltransferase (OST), (c) a potential consensus sequence motif polypeptide, and/or (d) a potential glycosylation inhibitor for use in the oligosaccharyltransferase (OST)—catalysed asparagine-linked (“N-linked”) glycosylation, comprising the steps of generating a three-dimensional model of the catalytic domain and/or the polypeptide binding site of the oligosaccharyltransferase (OST) of Campylobacter lari, and designing or selecting a potential component selected from (a) to (d) which optimizes the stereo chemical complementarity of said three-dimensional model(s) and the potential component.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.