Production of viral vaccine

US9884105B2 · kind B2 · utility

Assignee

• OLOGY BIOSERVICES INC. · US

Inventors

• Otfried Kistner · Wien, AT
• Falko-Guenter Falkner · Orth an der Donau, AT
• Hartmut Ehrlich · Paris, FR
• Noel Barrett · Klosterneuburg, AT

Key dates

• Filing date: Dec 16, 2009
• Grant date: Feb 6, 2018
• Expiry date: Dec 16, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2760/16161
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates, in general, to materials and methods for production of an improved vaccine against influenza virus, wherein the vaccine comprises a reassortant virus having a hemagglutinin gene and a neuraminidase gene from the same influenza A virus subtype or influenza B strain of virus and internal genes from a different influenza A virus subtype or influenza B strain of virus. In one aspect, the HA and NA genes and the internal genes are from a highly pathogenic H5N1 strain of influenza A.