Stable formulations of polypeptides and uses thereof

US9884117B2 · kind B2 · utility

Assignee

• Ablynx N.V. · BE

Inventors

• Ann Brigé · Ertvelde, BE
• Christine Labeur · Brugge, BE
• Marc Jozef Lauwereys · Haaltert, BE

Key dates

• Filing date: Sep 3, 2010
• Grant date: Feb 6, 2018
• Expiry date: Dec 4, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P19/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Stable formulations are provided that contain immunoglobulin single variable domains at a high concentration. The formulations are useful as pharmaceutical formulation and suitable for subcutaneous administration. The formulations can be transported and stored under various stress conditions. The invention further relates to containers and pharmaceutical units comprising such formulations and to methods for preparing and prophylactic and therapeutic uses of the formulations and pharmaceutical units of the invention.