Auristatin derivatives and conjugates thereof

US9884817B2 · kind B2 · utility

Assignee

• Novartis AG · CH

Inventors

• Bernhard Hubert Geierstanger · Solana Beach, US
• Jan Grunewald · San Diego, US
• Weijia Ou · San Diego, US
• Shifeng Pan · Gilroy, US
• Tetsuo Uno · San Diego, US
• Yongqin Wan · Irvine, US
• Xing Wang · San Diego, US

Key dates

• Filing date: Jun 11, 2015
• Grant date: Feb 6, 2018
• Expiry date: Jun 11, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K16/32
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are novel compounds of formula (I) as described herein:and the use of such peptides in making immunoconjugates (i.e Antibody Drug Conjugates) Also described herein are immunoconjugates (i.e Antibody Drug Conjugates) comprising such novel compound linked to an antigen binding moiety, such as an antibody; where such immunoconjugates are useful for treating cell proliferative disorders. The invention further provides pharmaceutical compositions comprising these immunoconjugates, compositions comprising the immunoconjugates with a therapeutic co-agent, and methods to use these immunoconjugates and compositions for treating cell proliferation disorders.