Sulphamoylpyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis B

US9884818B2 · kind B2 · utility

Assignee

• Janssen Sciences Ireland UC · IE

Inventors

• Koen Vandyck · Beringen, BE
• Geerwin Yvonne Paul Haché · Brasschaat, BE
• Stefaan Julien Last · Lint, BE
• David Craig MC GOWAN · Brussels, BE
• Geert Rombouts · Borsbeek, BE
• Wim Gaston Verschueren · Berchem, BE
• Pierre Jean-Marie Bernard Raboisson · Sligo, IE

Key dates

• Filing date: May 16, 2014
• Grant date: Feb 6, 2018
• Expiry date: May 16, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Inhibitors of HBV replication of Formula (ID)including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein X, Ra to Rd and R4 to R6 have the meaning as defined herein. The present invention also relates to processes for preparing compounds of Formula (ID), pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.