Polymorphic substance of yonkenafil hydrochloride, preparation method therefor, and composition and use thereof

US9884870B2 · kind B2 · utility

Assignee

• YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.

Inventors

• Haibo Zhang · Nanhu, CN
• Lingwu CHEN · 安丰镇, CN
• Xianfeng Lu · 安丰镇, CN
• Huixing Liang · 安丰镇, CN
• Yongfeng Wang · Baofeng County, CN
• Lianyong Shi · 安丰镇, CN
• Hongpeng Luo · 安丰镇, CN

Key dates

• Filing date: Nov 19, 2015
• Grant date: Feb 6, 2018
• Expiry date: Nov 19, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present application discloses an A-type polymorphic substance of yonkenafil hydrochloride and a preparation method, a composition and use thereof. The powder diffraction pattern of the A-type polymorphic substance of yonkenafil hydrochloride comprises diffraction peaks at three or more 2θ values selected from: 8.4±0.2°, 11.3±0.2°, 13.9±0.2°, 14.2±0.2°, 14.7±0.2°, 16.8±0.2°, 17.1±0.2°, 19.7±0.2°, 21.0±0.2°, 21.7±0.2°, 22.4±0.2°, 23.3±0.2°, 23.8±0.2°, 26.8±0.2°, 27.5±0.2°, 28.0±0.2°.