High affinity antibodies to human IL-6 receptor

US9884916B2 · kind B2 · utility

Assignee

• REGENERON PHARMACEUTICALS, INC. · US

Inventors

• Sean Stevens · San Diego, US
• Tammy T. Huang · Goldens Bridge, US
• Joel H. Martin · Putnam Valley, US
• Jeanette L. Fairhurst · Thornwood, US
• Ashique Rafique · Yonkers, US
• Eric Smith · New York, US
• Kevin J. Pobursky · Beacon, US
• Nicholas J. Papadopoulos · Lagrangeville, US
• James P. Fandl · Lagrangeville, US
• Gang Chen · Sammamish, US
• Margaret Karow · Newbury Park, US

Key dates

• Filing date: Apr 22, 2016
• Grant date: Feb 6, 2018
• Expiry date: Apr 22, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A human antibody or an antigen-binding fragment which binds human IL-6 receptor (hIL-6R) with a KD of about 500 pM or less and blocks IL-6 activity with an IC50 of 200 pM or less, is provided. In preferred embodiments, the antibody the antibody or antigen-binding fragment binds hIL-6R with an affinity at least 2-fold higher relative to its binding monkey IL-6R.