Bispecific heterodimeric diabodies and uses thereof

US9884921B2 · kind B2 · utility

Assignee

• PFIZER INC. · US

Inventors

• Chad May · New York, US
• Adam Reid Root · Byfield, US
• William Brady · Edmonds, US
• Lioudmila Tchistiakova · Andover, US
• Lidia Mosyak · Newton, US
• Laird Bloom · Needham, US
• Paul A. Moore · North Potomac, US
• Leslie S. Johnson · Travilah, US

Key dates

• Filing date: Jun 26, 2015
• Grant date: Feb 6, 2018
• Expiry date: Jun 26, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/94
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Bispecific heterodimeric diabody molecules and uses thereof in the treatment of cancer. The bispecific heterodimeric diabody molecules comprise two polypeptide chains that associate to form two epitope binding sites recognizing the P-cadherin tumor cell associated antigen and the CD3 T cell antigen.