Diagnosis and treatment of mycobacteria infections

US9885713B2 · kind B2 · utility

Assignee

• The Governors of the University of Alberta · CA

Inventors

• Stephane Evoy · St. Albert, CA
• Denis Arutyunov · Edmonton, CA
• Upasana Singh · Jamkhed, IN
• Christine Szymanski · Ottawa, CA

Key dates

• Filing date: Aug 1, 2014
• Grant date: Feb 6, 2018
• Expiry date: Aug 1, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2795/10322
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The invention provides isolated, purified, recombinant receptor binding proteins Gp-6, Gp-10 and Gp-31 from mycobacterium phage L5, and methods for producing these recombinant receptor binding proteins. The invention also provides the use of recombinant receptor binding proteins, including Gp-6, Gp-10 and Gp-31, as probes for the identification and diagnosis of mycobacterium infections and conditions caused by mycobacterium. Further provided by the invention are methods of targeting mycobacteria using recombinant receptor binding proteins, including Gp-6, Gp-10 and Gp-31. Other methods provided by the invention include the use of recombinant receptor binding proteins, such as Gp-10, in diagnostic assays for diseases, such as Johne's disease, in animals, including ruminants.