Functional recovery of human lungs for transplantation

US9888680B2 · kind B2 · utility

Assignee

• The Trustees of Columbia University in the City of New York · US

Inventors

• Gordana Vunjak-Novakovic · New York, US
• Joshua Sonett · Waldwick, US
• John O'Neill · New York, US
• Matthew Bacchetta · New York, US
• Donald Freytes · Pittsburgh, US
• Gopal Singh · New York, US
• Scott Kanner · New York, US

Key dates

• Filing date: Apr 4, 2014
• Grant date: Feb 13, 2018
• Expiry date: Apr 4, 2034

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A01N1/126
• WIPO field: Basic materials chemistry
• WIPO sector: Chemistry

Abstract

The vasculature of a donor lung is perfused with a lung preserving fluid to preserve its structure. At the same time, a decellularization fluid is perfused through the airways, which strips away donor cells. The decellularized region is then seeded with pulmonary cells of the transplant recipient, which regenerate the lung. The pulmonary cells may be derived from stem cells, and the decellularization can be targeted to reduce the quantity of cells required.