Patent · US Active

Amorphous tecovirimat preparation

US9889119B2 · kind B2 · utility

0Cited by

0References

11Claims

0Family size

Assignee

Siga Technologies, Inc. · US

Inventors

Shanthakumar R. Tyavanagimatt · Corvallis, US
N K Peter Samuel · Corvallis, US
Joseph Paz · Corvallis, US
Ying Tan · Millbrae, US
Dennis E. Hruby · Albany, US

Key dates

Filing date	Apr 27, 2017
Grant date	Feb 13, 2018
Priority date	—
Expiry date	Apr 27, 2037

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D209/76
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Disclosed are methods for the preparation of amorphous N-[(3aR,4R,4aR,5aS,6S,6aS)-3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindo1-2(1H)-yl]-4-(trifluoromethyl)-benzamide for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the orthopoxvirus. Also disclosed are methods for the preparation of amorphous solid dispersion of N-[(3aR,4R,4aR,5aS,6S,6aS)-3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindo1-2(1H)-yl]-4-(trifluoromethyl)-benzamide.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.