Treating renal and liver dysfunction with TLR4 antagonists
US9889176B2 · kind B2 · utility
1Cited by
1References
6Claims
0Family size
Assignee
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Key dates
| Filing date | Aug 17, 2011 |
| Grant date | Feb 13, 2018 |
| Priority date | — |
| Expiry date | Aug 17, 2031 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/52
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention derives from the finding that increased levels of Toll like receptor 4 (TLR4) is associated with liver failure and renal dysfunction and/or brain dysfunction and that by decreasing TLR4 levels in vivo, the kidney and brain consequences of liver disease that are precipitated by superimposed infection or inflammation may be reduced. Accordingly, the invention provides TLR4 antagonists for use in a method of treating an individual suffering from liver disease presenting with renal or brain dysfunction.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.