Lipid-based drug carriers for rapid penetration through mucus linings

US9889208B2 · kind B2 · utility

Assignee

• THE JOHNS HOPKINS UNIVERSITY · US

Inventors

• Justin Hanes · Baltimore, US
• Kannie Wai Yan Chan · Baltimore, US
• Michael T. McMahon · Syracuse, US
• Ming Yang · Towson, US
• Tao Yu · Shanghai, CN

Key dates

• Filing date: May 6, 2013
• Grant date: Feb 13, 2018
• Expiry date: Mar 23, 2034

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S977/907
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Mucus-penetrating liposomal nanoparticles and methods of making and using thereof are described herein. The nanoparticles contain one or more lipids, one or more PEG-conjugated lipids, and optionally one or more additional materials that physically and/or chemically stabilize the particles. The nanoparticle have an average diameter of about 100 nm to about 300 nm, preferably from about 100 nm to about 250 nm, more preferably from about 100 nm to about 200 nm. The particles are mobile in mucus. The liposomes can further contain one or more therapeutic, prophylactic, and/or diagnostic agent to be delivered to a mucosal surface, such as the CV tract, the colon, the nose, the lungs, and/or the eyes. The liposomes can further contain one or more CEST agents to allow real time imaging of the particles in a live animal. The particles may also further contain an imaging agent, such as a fluorescent label.