Implantable devices for bone or joint defects

US9889235B2 · kind B2 · utility

Assignee

• University of Utah Research Foundation · US

Inventors

• Amanda Elaine Brooks · South Jordan, US
• David W. Grainger · Salt Lake City, US
• Kristofer D. Sinclair · Salt Lake City, US
• Benjamin Delbert Brooks · South Jordan, US

Key dates

• Filing date: Feb 5, 2014
• Grant date: Feb 13, 2018
• Expiry date: Feb 5, 2034

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B29L2031/7532
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

In one aspect, the invention provides an implantable device comprising a uniform mixture of components including degradable polymer, inorganic bone particulate either natural or synthetic, a drug, and a soluble microporagen. In some embodiments, the uniform mixture further includes a soluble polymer macroporagen. In some embodiments, the uniform mixture is coated with an immobilized outer porous layer comprising or consisting of synthetic or natural inorganic bone granules. In further aspects, the invention provides an implantable device comprising a composite core of degradable polymer, bone, and a drug, and a coating comprising or consisting of microporous bone overlayer covering the degradable composite core.