2-halo-5-alkynyl-pyridyl nicotinic ligands

US9890137B2 · kind B2 · utility

Assignee

• Georgetown University · US

Inventors

• Yingxian Xiao · Potomac, US
• Kenneth J. Kellar · Bethesda, US
• Milton L. Brown · Brookeville, US
• Mikell Paige · Fairfax, US
• Yong-Jun Liu · Oakville, CA

Key dates

• Filing date: Mar 26, 2014
• Grant date: Feb 13, 2018
• Expiry date: Mar 26, 2034

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed are heterocyclic compounds that are ligands for nicotinic acetylcholine receptors. The compounds are useful for treating a mammal suffering from any one of a range of therapeutic indications, including Alzheimer's disease, Parkinson's disease, dyskinesias, Tourette's syndrome, schizophrenia, attention deficit disorder, anxiety, pain, depression, obsessive compulsive disorder, chemical substance abuse, alcoholism, memory deficit, pseudodementia, Ganser's syndrome, migraine pain, bulimia, obesity, premenstrual syndrome or late luteal phase syndrome, tobacco abuse, post-traumatic syndrome, social phobia, chronic fatigue syndrome, premature ejaculation, erectile difficulty, anorexia nervosa, disorders of sleep, autism, mutism, trichotillomania, and hypothermia.