Taxane compound, and preparation method and use thereof

US9890175B2 · kind B2 · utility

Assignee

• JIANGSU TASLY DIYI PHARMACEUTICALS CO., LTD. · CN

Inventors

• Wei Zhou · Tianjin, CN
• Yunrong Jing · Tianjin, CN
• Yongfeng Wang · Baofeng County, CN
• Guocheng Wang · 安丰镇, CN

Key dates

• Filing date: Nov 21, 2014
• Grant date: Feb 13, 2018
• Expiry date: Nov 21, 2034

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are taxanes compounds having the structure of formula I, preparation method thereof, and uses of compositions having the compound, pharmaceutical salts and solvates thereof as active ingredients in the preparation of oral antitumor drugs. In the formula, R1 is —COR6, —COOR6, and —CONR7aR7b; R2 is C1-C6 alkyl, C1-C6 alkenyl group, a substituted hydrocarbon group, a heterocyclic group, an aromatic group or a substituted aromatic group; R3 is —OR6, —OCOOR6, —OCOSR6, and —OCONR7aR7b; R4 is —OR6, —OCOOR6, —OCOSR6, —OCONR7aR7b, H, and OH; R6 is C1-C6 alkyl, C1-C6 alkenyl, C1-C6 alkynyl group, a substituted hydrocarbon group, an aromatic group or a heterocyclic group; and R7a and R7b are respectively hydrogen, a hydrocarbon group, a substituted hydrocarbon group or a heterocyclic group.