Patent · US Active

Recombinant bacterial cells producing (S)-2-amino-6-hydroxypimelate

US9890405B2 · kind B2 · utility

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Key dates

Filing dateAug 21, 2013
Grant dateFeb 13, 2018
Priority date—
Expiry dateAug 21, 2033

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC12P13/04
  • WIPO fieldBiotechnology
  • WIPO sectorChemistry

Abstract

A chemical having the formula (S) 2-amino-6-hydroxypimelate. (S)-2-amino-6-hydroxypimelate can be made using a method comprising culturing a cell comprising an exogenous nucleic acid sequence encoding an enzyme that catalyzes the substrate to product conversion of (S)-2-amino-6-oxopimelate to (S)-2-amino-6-hydroxypimelate and separating the (S)-2-amino-6-hydroxypimelate. The cell may be a recombinant microorganism for producing aminocaproic acid or hexamethylenediamine from (S)-2-amino-6-hydroxypimelate comprising at least one exogenous nucleic acid sequence that expresses at least one polypeptide with substrate preference for homolysine, and amino acid decarboxylase with substrate preference for alpha-aminopimelate.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.