Method for producing cathine

US9890406B2 · kind B2 · utility

Assignee

• Forschungszentrum Jülich GmbH · DE

Inventors

• Doerte Rother · Gerstungen, DE
• Martina Pohl · Aachen, DE
• Torsten Sehl · Offenburg, DE
• Alvaro Gomez Baraibar · Delft, NL

Key dates

• Filing date: May 17, 2014
• Grant date: Feb 13, 2018
• Expiry date: May 17, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Y206/01
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A method for producing cathine ((1S,2S)-norpseudoephedrine), in which, in a first reaction step, benzaldehyde is reacted with an acetyl donor according to formula (1), where R═H or COOH, by way of an (S)-selective lease to yield an enantiomer mixture according to formulas (2) and (3) and, in a second step, the compound according to formula (3) is reacted with an amine donor by way of an (S)-selective transaminase to yield (1S,2S)-norpseudoephedrine.