Systems and methods for ex-vivo organ care and for using lactate as an indication of donor organ status
US9894894B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 16, 2012 |
| Grant date | Feb 20, 2018 |
| Priority date | — |
| Expiry date | Dec 18, 2032 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA01N1/10
- WIPO fieldBasic materials chemistry
- WIPO sectorChemistry
Abstract
The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate the: 1) The overall perfusion status of an isolated heart and 2) The metabolic status of an isolated heart and 3) the overall vascular patency of an isolated donor heart. This aspect of the present invention uses the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.