Formulations for targeted release of agents to low pH tissue environments or cellular compartments and methods of use thereof
US9895451B2 · kind B2 · utility
3Cited by
16References
28Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 18, 2014 |
| Grant date | Feb 20, 2018 |
| Priority date | — |
| Expiry date | Nov 18, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N15/87
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Polyamine-co-ester-co-ortho ester) polymers, methods of forming active agent-load nanoparticles therefrom, and methods of using the nanoparticles for drug delivery are disclosed. The nanoparticles can be coated with an agent that reduces surface charge, an agent that increases cell-specific targeting, or a combination thereof. Typically, the loaded nanoparticles are less toxic, more efficient at drug delivery, or a combination thereof compared to a control or other transfection reagents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.