Non-fouling, anti-microbial, anti-thrombogenic graft—from compositions

US9895470B2 · kind B2 · utility

Assignee

• Semprus Biosciences Corp. · US

Inventors

• Jun Li · Ningbo City, CN
• Trevor Squier · Peabody, US
• Zheng Zhang · Cambridge, US
• Chad C. Huval · Somerville, US
• William Shannan O'Shaughnessy · Cambridge, US
• Michael Hencke · Cambridge, US
• Michael A. Bouchard · Wyomissing, US
• Christopher R. Loose · Cambridge, US

Key dates

• Filing date: Dec 7, 2009
• Grant date: Feb 20, 2018
• Expiry date: Dec 27, 2035

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T442/2525
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

Substrates, optionally coated with an undercoating layer, having grafted there from one or more non-fouling materials are described herein. The non-fouling, polymeric material can be grafted from a variety of substrate materials, particularly polymeric substrates and/or polymeric undercoating layers. The graft-from techniques described herein can result in higher surface densities of the non-fouling material relative to graft-to formulations. Graft-from methods can be used to produce covalently tethered polymers. The compositions described herein are highly resistant protein absorption, particularly in complex media and retain a high degree of non-fouling activity over long periods of time. The compositions described herein may also demonstrate antimicrobial and/or anti-thrombogenic activity. The non-fouling material can be grafted from the substrate, or optionally from an undercoating layer on the substrate, preferably without significantly affecting the mechanical and/or physical properties of the substrate material.