Pyrazole-substituted arylamides as P2X3 and P2X2/3 antagonists

US9896439B2 · kind B2 · utility

Assignee

• Roche Palo Alto LLC · US

Inventors

• Li Chen · Sha Tin, CN
• Michael Patrick Dillon · Mill Valley, US
• Lichun Feng · Shanghai, CN
• Ronald Charles Hawley · Oakland, US
• Minmin Yang · Nanjing, CN

Key dates

• Filing date: Dec 19, 2016
• Grant date: Feb 20, 2018
• Expiry date: Dec 19, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula I:or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted pyrazolyl, and R2, R3, R4, R5, R6, R7 and R8 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X3 and/or a P2X2/3 receptor antagonists and methods of making the compounds.