Enhancing the stability and purity and increasing the bioavailability of human milk oligosaccharides or precursors or blends thereof

US9896470B2 · kind B2 · utility

Assignee

• GLYCOM A/S · DK

Inventors

• Andreas Schroven · Templin, DE
• Gyula Dekany · Budapest, HU
• Peter Erdmann · Bern, CH
• Andrea Schwarz · Bern, CH

Key dates

• Filing date: Jun 14, 2013
• Grant date: Feb 20, 2018
• Expiry date: Jun 14, 2033

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A23V2200/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present application discloses a method for enhancing the stability of a human milk oligosaccharide (HMO) or a HMO precursor or a HMO blend when stored for extended periods at temperatures above 25° C. by spray-drying an aqueous solution of the HMO or HMO precursor to remove at least 90% of the water and providing a HMO or a HMO precursor or a HMO blend with a specific glass transition temperature. Also disclosed is a method for removing organic solvent residues from a human milk oligosaccharide (HMO) or a HMO precursor or a HMO blend by spray drying. Also disclosed is a method of enhancing the bioavailability of a human milk oligosaccharide (HMO) or a HMO precursor or a HMO blend by spray drying.