Protected monomer and method of final deprotection for RNA synthesis
US9896472B2 · kind B2 · utility
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7Claims
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Key dates
| Filing date | Sep 14, 2015 |
| Grant date | Feb 20, 2018 |
| Priority date | — |
| Expiry date | Oct 18, 2035 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of deprotecting a solid support bound polynucleotide includes the step of contacting the polynucleotide with a composition comprising a diamine under conditions sufficient to deprotect the 2′-protected ribonucleotide residue. The solid support bound polynucleotide has at least one 2′-protected ribonucleotide residue, which has the following structure:wherein BP is a protected or unprotected heterocycle; R12 is a protecting group selected from a hydrocarbyl, a substituted hydrocarbyl, an aryl, and a substituted aryl; X is O or S; and PG is a thionocarbamate protecting group.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.