Mutated immunoglobulin-binding polypeptides
US9896486B2 · kind B2 · utility
3Cited by
3References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 8, 2014 |
| Grant date | Feb 20, 2018 |
| Priority date | — |
| Expiry date | Jul 8, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K16/00
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
A polypeptide with improved alkaline stability, which polypeptide comprises a mutant of a B or C domain of Staphylococcus Protein A, as specified by SEQ ID NO 1 or SEQ ID NO 2, or of Protein Z, as specified by SEQ ID NO 3, wherein at least the glutamine residue at position 9 has been mutated to an amino acid other than asparagine. The invention also discloses multimers of said polypeptide, as well as separation matrices comprising the multimers or polypeptides.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.