Dilute filtration sterilization process for viscoelastic biopolymers
US9896518B2 · kind B2 · utility
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19Claims
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Key dates
| Filing date | Sep 10, 2013 |
| Grant date | Feb 20, 2018 |
| Priority date | — |
| Expiry date | Sep 10, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P19/26
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Manufactured hyaluronic acid products are used in numerous surgical applications including viscoelastic supplementation for the treatment of osteoarthritis, however, traditional sterilization techniques result in the breakdown of such high molecular o weight viscoelastic biopolymers and are thus unsuitable. Disclosed are processes for obtaining concentrated sterile solutions of high molecular weight biopolymers such as hyaluronic acid. The processes include filter sterilization with a dilute preparation of the biopolymer, and concentration of the dilute filter sterilized biopolymer by ultrafiltration to a desired concentration.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.