Chromatography columns
US9897578B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Sep 19, 2013 |
| Grant date | Feb 20, 2018 |
| Priority date | — |
| Expiry date | Nov 9, 2033 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2030/524
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A chromatography column (2) containing a bed of packed particles (22, 24, 26, 28, 30), wherein the packed particles comprise fused core particles and the particle diameters of the packed particles vary along the column. Preferably, the particles (2, 24, 26, 28, 30) are arranged according to their average particle diameter, in order of increasing average particle diameter from the inlet end (4) to the outlet end (6). The bed may comprise a plurality of bed sections and each bed section has an average particle diameter calculated from the particles in that section and there are at least two different average particle diameter bed sections, wherein the particles of each bed are separated from particles of an adjacent bed by a partition that is liquid permeable to allow through a flow of mobile phase. A high column efficiency can be provided with lower pressure drop per unit length of the column.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.