Antibodies against chikungunya virus and uses thereof

US9902765B2 · kind B2 · utility

Assignees

• Integral Molecular, Inc. · US
• BLOOD SYSTEMS RESEARCH INSTITUTE · US

Inventors

• Benjamin J. Doranz · Narberth, US
• Kimberly-Anne Mattia · Cold Point, US
• Kristen Kahle · Philadelphia, US
• Graham Simmons · San Francisco, US
• Rachel Hua-Ning Fong · Philadelphia, US
• Soma Banerjee · Ames, US

Key dates

• Filing date: Jul 21, 2014
• Grant date: Feb 27, 2018
• Expiry date: Jul 21, 2034

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Embodiments disclosed herein provide for antibodies, including neutralizing antibodies, against Chikungunya virus, uses thereof, and methods of identifying antibodies, including neutralizing antibodies, against Chikungunya virus. In some embodiments, antibodies that binds to a CHIKV antigen, wherein the antigen is the CHIKV E1, E2, E3 protein, or any heterocomplex thereof are provided. In some embodiments, the antibody is an isolated antibody, a neutralizing antibody, a recombinant antibody, or any combination thereof. In some embodiments, the antibodies described herein bind to an epitope of E2 Domain A, E2 Domain B, or E1 Domain II of the CHIKV antigen. In some embodiments, the antigen is E2 protein.