Complex chromosome engineering for production of human antibodies in transgenic animals
US9902970B2 · kind B2 · utility
3Cited by
3References
22Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 5, 2013 |
| Grant date | Feb 27, 2018 |
| Priority date | — |
| Expiry date | Aug 7, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2800/208
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention relates to large-scale production of human antibodies by transgenic animals with high production of fully human IgG up to >10 g/L in sera with human IgG1 subclass dominancy. This invention also supports a feasibility of complex chromosome engineering for complicated genetic studies in non-murine mammalian species.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.