Conjugate-based antifungal and antibacterial prodrugs

US9907812B2 · kind B2 · utility

Assignee

• VYOME BIOSCIENCES PVT. LTD. · IN

Inventors

• Abhijit S. Bapat · Delhi, IN
• Gauthami Mahesh · Noida, IN
• Rajesh S. Gokhale · New Delhi, IN
• Sayali Shah · Noida, IN
• Shiladitya Sengupta · Waltham, US
• Sudhanand Prasad · Ghaziabad, IN
• Sumana Ghosh · Delhi, IN
• Suresh Rameshlal CHAWRAI · Delhi, IN
• Nidhi Arora · Cupertino, US
• D. Sreedhar Reddy · Darsi, IN
• Mallika Mishra · Ghaziabad, IN
• Kirti Bajaj · Barwala, IN

Key dates

• Filing date: Jun 22, 2012
• Grant date: Mar 6, 2018
• Expiry date: Nov 9, 2032

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2800/57
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides conjugate-based antifungal or antibacterial prodrugs formed by coupling at least one anti-fungal agent or antibacterial agent with at least one linker and/or carrier. The prodrugs are of formula: (i) (AFA)m-X-(L)n; (ii) [(AFA)m′-X]p-L; (iii) AFA-[X-(L)n′]q; or (iv) (AFA)m″-X, wherein: AFA is an antifungal agent or an antibacterial agent; L is a carrier; X is a linker; m ranges from 1 to 10; n ranges from 2 to 10; m′ is 1 to 10; p is 1 to 10; n′ is 1 to 10; and q is 1 to 10, provided that q′ and n are not both 1; and m″ is 1 to 10. The invention also provides nanoparticles comprising the conjugate-based prodrugs. Additionally, the invention also provides non-conjugated antifungal and antibacterial agents in the form of nanoparticles.