Compositions with a rheological modifier to reduce dissolution variability

US9907851B2 · kind B2 · utility

Assignee

• Durect Corporation · US

Inventors

• Su Il Yum · Los Altos, US
• Wendy Chao · San Jose, US
• Huey-Ching Su · San Jose, US
• Roger Fu · Saratoga, US
• Michael Zamloot · Austin, US
• Karl Bratin · Groton, US
• Ravi M. Shanker · Groton, US

Key dates

• Filing date: Dec 15, 2016
• Grant date: Mar 6, 2018
• Expiry date: Dec 15, 2036

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides compositions (e.g., extended release compositions) which exhibit a desirable pharmacokinetic profile of an active agent while providing reduced dissolution sample variability, e.g., in the form of reduced inter-capsule variability and/or a reduction in storage-time dependent change in mean release of the active agent from the composition. Related methods of making and administering the disclosed compositions and formulations are also provided.