Aryl ethers and uses thereof
US9908845B2 · kind B2 · utility
14Cited by
6References
28Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 5, 2014 |
| Grant date | Mar 6, 2018 |
| Priority date | — |
| Expiry date | Sep 5, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2603/94
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present disclosure relates to HIF-2α inhibitors and methods of making and using them for treating cancer. Certain compounds were potent in HIF-2α scintillation proximity assay, luciferase assay, and VEGF ELISA assay, and led to tumor size reduction and regression in 786-O xenograft bearing mice in vivo.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.