Patent · US Active

Single-chain trail-receptor agonist proteins

US9908927B2 · kind B2 · utility

3Cited by

8References

27Claims

0Family size

Assignees

Abb Vie Inc. · US
APOGENIX AG · DE

Inventors

Oliver Hill · Neckarsteinach, DE
Christian Gieffers · Dossenheim, DE
Meinolf Thiemann · Schriesheim, DE
Fritz G. Buchanan · Salem, US
Darren C. Phillips · Whittlesea, AU
Susan E. Lappe · Riverwoods, US

Key dates

Filing date	Apr 23, 2015
Grant date	Mar 6, 2018
Priority date	—
Expiry date	Apr 23, 2035

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2319/30
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Provided herein are specific TRAIL receptor agonist proteins, nucleic acids encoding the same, and methods of treating a subject having a TRAIL-associated disease or disorder. The TRAIL receptor agonist proteins provided herein comprise three soluble TRAIL domains and an Fc fragment. The TRAIL receptor agonist proteins are substantially non-aggregating and suitable for therapeutic, diagnostic and/or research applications.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.