Monoclonal antibodies against antithrombin β

US9908942B2 · kind B2 · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Ye Jin · San Ramon, US
• John E. Murphy · Mobile, US
• Terry Hermiston · Corte Madera, US
• Timothy Myles · Sunnyvale, US
• Frank Dittmer · Goldkronach, DE
• Michael Strerath
• Uwe Gritzan · Cologne, DE

Key dates

• Filing date: Mar 14, 2014
• Grant date: Mar 6, 2018
• Expiry date: Dec 6, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/565
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This patent document relates to antibodies, antigen-binding antibody fragments (Fabs), and other protein scaffolds, directed against human antithrombin β complexed with heparin and/or heparin-like structure (ATβH). These ATβH binding proteins can block the anti-coagulant activity of ATβ to induce coagulation. Therapeutic uses of these antibodies and binders are described herein as are methods of panning and screening specific antibodies.