Measurement and comparison of immune diversity by high-throughput sequencing
US9909180B2 · kind B2 · utility
21Cited by
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Key dates
| Filing date | Feb 4, 2014 |
| Grant date | Mar 6, 2018 |
| Priority date | — |
| Expiry date | Apr 11, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/156
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
High-throughput long read sequencing is used to perform immunogenomic characterization of expressed antibody repertoires in the context of vaccination. Informatic analysis allows global characterizations of isotype distributions, determination of the lineage structure of the repertoire and measure age and antigen related mutational activity. Global analysis of the immune system's clonal structure provides direct insight into the effects of vaccination and provides a detailed molecular portrait of age-related effects.
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