Polyvalent functionalized nanoparticle-based in vivo diagnostic system
US9910035B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 16, 2014 |
| Grant date | Mar 6, 2018 |
| Priority date | — |
| Expiry date | Nov 24, 2034 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61B2562/043
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A system for modulating a response signal includes polyvalent functionalized nanoparticles configured to bind with target analytes located on a surface of a cell, a detector configured to detect an analyte response signal transmitted from the body, a modulation source configured to modulate the analyte response signal, and a processor configured to non-invasively detect the one or more target analytes by differentiating the analyte response signal from a background signal, at least in part, based on the modulation. The analyte response signal is related to the binding interaction of the target analytes on the cell surface with the polyvalent functionalized nanoparticles. In some examples, the system may also include magnetic particles and a magnetic field source sufficient to distribute the magnetic particles into a spatial arrangement in the body. The analyte response signal may be differentiated from the background signal, at least in part, based on modulation of the signals due, at least in part, to the spatial arrangement of the magnetic particles.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.