Methods of treating cancer using compositions comprising perillyl alcohol derivative
US9913838B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Oct 8, 2014 |
| Grant date | Mar 13, 2018 |
| Priority date | — |
| Expiry date | Oct 8, 2034 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/0085
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method for treating brain metastases of a cancer in a mammal includes administering to the mammal a therapeutically effective amount of a perillyl alcohol carbamate, such as TMZ-POH. The brain metastases can be originated or spread from breast cancer. The perillyl alcohol derivative may be perillyl alcohol conjugated with a therapeutic agent, such as a chemotherapeutic agent. The chemotherapeutic agents that may be used in the present invention include a DNA alkylating agent, a topoisomerase inhibitor, an endoplasmic reticulum stress inducing agent, a platinum compound, an antimetabolite, an enzyme inhibitor, and a receptor antagonist.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.