Bile acids and biguanides as protease inhibitors for preserving the integrity of peptides in the gut
US9913850B2 · kind B2 · utility
0Cited by
7References
6Claims
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Assignee
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Key dates
| Filing date | Oct 1, 2009 |
| Grant date | Mar 13, 2018 |
| Priority date | — |
| Expiry date | Jun 29, 2031 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/28
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention relates to methods of preserving the integrity of peptides in the gut. In particular it concerns the use of certain compounds as inhibitors of gut proteases. Compounds identified as having gut protease inhibitory activity are biguanides, certain bile acids and pharmaceutically acceptable salts of these compounds. This activity makes these compounds useful for co-administration with prophylactic or therapeutic peptides. This invention relates to methods of inhibiting gut proteases and peptide formulations comprising these gut protease inhibitor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.